DNA mismatch repair protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with MSH3 to form the MutSβ DNA repair complex. MSH2 is involved in many different forms of DNA repair, including transcription-coupled repair, homologous recombination, and base excision repair.
Mutations in the gene MSH2 are associated with microsatellite instability and certain types of cancer, especially hereditary colorectal cancer HNPCC nepriyatnogo.
- 875 - 934 of MSH2 The binding regions on MSH2 are identical when binding to either MSH 3 or MSH 6. Adenine nucleotide binding regions in MSH 3 and MSH2 are not
- its homology to MSH2 The identification of the human GTBP gene and subsequent amino acid sequence availability showed that yeast MSH 6 and human GTBP
- keratoacanthomas and sebaceous tumors. The genes affected are MLH1, MSH2 and more recently, MSH 6, and are involved in DNA mismatch repair. Muir Torre syndrome
- MSH 4 gene. The MSH 4 and MSH 5 proteins form a hetero - oligomeric structure heterodimer in yeast and humans. In the yeast Saccharomyces cerevisiae MSH 4
- MutS protein homolog 5 is a protein that in humans is encoded by the MSH 5 gene. This gene encodes a member of the mutS family of proteins that are involved
- people with a germline DNA mutation in one of the MMR genes MLH1, MSH2 MSH 6, and PMS 2 or the EPCAM gene, identified by genetic testing. Candidates for
- seven DNA mismatch repair proteins in humans are MLH1, MLH3, MSH2 MSH 3, MSH 6, PMS1 and PMS 2 In addition, there are Exo1 - dependent and Exo1 - independent
- α - melanocyte - stimulating hormone α - MSH β - melanocyte - stimulating hormone β - MSH and γ - melanocyte - stimulating hormone γ - MSH that are produced by cells in
- MSH and is produced from proopiomelanocortin POMC It is an agonist of the MC1, MC3, MC4, and MC5 receptors. It exists in three forms, γ1 - MSH γ 2 - MSH
- In eukaryotes, MutS homologs form two major heterodimers: Msh2 Msh 6 MutSα and Msh2 Msh 3 MutSβ The MutSα pathway is involved primarily in base substitution