ⓘ Synaptojanin

                                     

ⓘ Synaptojanin

Synaptojanin is a protein involved in vesicle uncoating in neurons. This is an important regulatory lipid phosphatase. It dephosphorylates the D-5 position phosphate from phosphatidylinositol -trisphosphate and Phosphatidylinositol -bisphosphate. It belongs to family of 5-phosphatases, which are structurally unrelated to D-3 inositol phosphatases like PTEN. Other members of the family of 5phosphoinositide phosphatases include OCRL, SHIP1, SHIP2, INPP5J, INPP5E, INPP5B, INPP5A and SKIP.

                                     
  • Synaptojanin 1 is a protein that in humans is encoded by the SYNJ1 gene. This gene encodes a phosphoinositide phosphatase that regulates levels of membrane
  • most notably found at the amino terminal of the inositol 5 - phosphatase synaptojanin Synaptic vesicles are recycled with remarkable speed and precision in
  • SH3 - domain GRB2 - like 2 Micheva, K D Kay B K McPherson P S Oct 1997 Synaptojanin forms two separate complexes in the nerve terminal. Interactions with
  • Synaptojanin 2 is a protein that in humans is encoded by the SYNJ2 gene. The gene is a member of the inositol - polyphosphate 5 - phosphatase family. The encoded
  • Synaptojanin - 2 - binding protein is a protein that in humans is encoded by the SYNJ2BP gene. SYNJ2BP has been shown to interact with: ACVR2A, ACVR2B, LRP1
  • 1997 The SH3p4 Sh3p8 SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2 - like Src homology 3 domain Proc. Natl. Acad
  • 1997 The SH3p4 Sh3p8 SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2 - like Src homology 3 domain Proc. Natl. Acad
  • Osterweil EK, Mooseker MS February 2007 Myosin 1E interacts with synaptojanin - 1 and dynamin and is involved in endocytosis FEBS Letters. 581 4
  • Gene: DNM1 dynamin 1 Micheva KD, Kay BK, McPherson PS October 1997 Synaptojanin forms two separate complexes in the nerve terminal. Interactions with
  • libraries displayed on phage lambda reveals new potential partners of synaptojanin 1 Journal of Molecular Biology. 307 5 1329 39. doi: 10.1006 jmbi
  • involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin endophilin, and clathrin. Isoforms that are expressed in muscle and
  • AP endonuclease proteins EC 4.2.99.18, DNase I proteins EC 3.1.21.1, Synaptojanin an inositol - 1, 4, 5 - trisphosphate phosphatase EC 3.1.3.56 Sphingomyelinase
  • libraries displayed on phage lambda reveals new potential partners of synaptojanin 1 J. Mol. Biol. 307 5 1329 39. doi: 10.1006 jmbi.2001.4572. PMID 11292345