ⓘ Transferrin receptor

                                     

ⓘ Transferrin receptor

Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. It imports iron by internalizing the transferrin-iron complex through receptor-mediated endocytosis. The existence of a receptor for transferrin iron uptake had been recognized over half a century back. Earlier two transferrin receptors in humans, transferrin receptor 1 and transferrin receptor 2 had been characterized and until recently cellular iron uptake was believed to occur chiefly via these two well documented transferrin receptors. Both these receptors are transmembrane glycoproteins. TfR1 is a high affinity ubiquitously expressed receptor while expression of TfR2 is restricted to certain cell types and is unaffected by intracellular iron concentrations. TfR2 binds to transferrin with a 25-30 fold lower affinity than TfR1. Although TfR1 mediated iron uptake is the major pathway for iron acquisition by most cells and especially developing erythrocytes, several studies have indicated that the uptake mechanism varies depending upon the cell type. It is also reported that Tf uptake exists independent of these TfRs although the mechanisms are not well characterized. The multifunctional glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase has been shown to utilize post translational modifications to exhibit higher order moonlighting behavior wherein it switches its function as a holo or apo transferrin receptor leading to either iron delivery or iron export respectively.

                                     
  • biological fluids of vertebrates.When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell, e.g., erythroid
  • Transferrin receptor 2 TfR2 is a protein that in humans is encoded by the TFR2 gene. This protein is involved in the uptake of transferrin - bound iron
  • Transferrin receptor protein 1 TfR1 also known as Cluster of Differentiation 71 CD71 is a protein that in humans is encoded by the TFRC gene. TfR1
  • transferrin receptor conventionally refers to the cleaved extracellular portion of transferrin receptor 1 that is released into serum. This receptor is
  • a type of Iron overload disorder associated with deficiencies in transferrin receptor 2. It exhibits an autosomal recessive inheritance pattern. RESERVED
  • transferrin receptor mRNA. The transferrin receptor mRNA is rapidly degraded without the IRE - BP attached to it. The cell stops producing transferrin receptors
  • saturation of transferrin Unsaturated iron binding capacity UIBC Transferrin receptor TfR Complete blood count CBC especially: Hemoglobin, EVF or
  • circulating iron uptake by regulating the interaction of the transferrin receptor with transferrin The HFE gene contains 7 exons spanning 12 kb. The full - length
  • on their surfaces. These receptors also have a high affinity for coated pits. Like the LDL receptor the transferrin receptor is internalised into a coated
  • MVBs Removal of recycling molecules such as transferrin receptors and mannose 6 - phosphate receptors continues during this period, probably via budding
  • 2000 Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein