ⓘ SOS1

                                     

ⓘ SOS1

SOS1 is a guanine nucleotide exchange factor GEF which interacts with RAS proteins to turn GDP into GTP, or from an inactive state to an active state to signal cell proliferation. RAS genes e.g., MIM 190020 encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins GAPs. The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the son of sevenless gene Sos contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange.

                                     
  • ommatidium fails to form. Similarly, the mammalian orthologues of Sos SOS1 and SOS 2, function downstream of many growth factor and adhesion receptors
  • and 126, 143 in codon 1083 of the SOS1 gene, meaning there is a mutation in SOS1 This causes a problem because SOS1 introduces a frameshift mutation and
  • antiporter which is near SOS1 The SOS 2 - SOS 3 complex is necessary for generating the full response of SOS1 But in mutants missing SOS 2 - SOS 3, Sodium can directly
  • formal notation SOS is written with an overscore line, to indicate that the Morse code equivalents for the individual letters of SOS are transmitted
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  • Sos del Rey Catolico in Aragonese: Sos d o Rei Catolico is a historic town and municipality in the Cinco Villas comarca, province of Zaragoza, in Aragon