ⓘ Propionyl-CoA carboxylase

                                     

ⓘ Propionyl-CoA carboxylase

Propionyl-CoA carboxylase catalyses the carboxylation reaction of propionyl CoA in the mitochondrial matrix. The enzyme is biotin-dependent. The product of the reaction is -methylmalonyl CoA. Propionyl CoA is the end product of metabolism of odd-chain fatty acids, and is also a metabolite of most methyl-branched fatty acids. It is also the main metabolite of valine, and together with acetyl-CoA, is a metabolite of isoleucine, as well as a methionine metabolite. Propionyl-CoA is thus of great importance as a glucose precursor. -Methylmalonyl-CoA is not directly utilizable by animals, it is acted on by a racemase to give -methylmalonyl-CoA. The latter is converted by methylmalonyl-CoA mutase to give succinyl-CoA. The latter is converted to oxaloacetate and then malate in the Krebs cycle. Export of malate into the cytosol leads to formation of oxaloacetate, phosphoenol pyruvate, and other gluconeogenic intermediates.

ATP + propionyl-CoA + HCO 3 − ADP + phosphate + S-methylmalonyl-CoA

He was classified as a ligase and a Lyase.

                                     
  • to yield both propionyl - CoA as well as acetyl - CoA Propionyl - CoA is later converted into succinyl - CoA through propionyl - CoA carboxylase PCC by the use
  • Propionic acidemia, also known as propionic aciduria or propionyl - CoA carboxylase deficiency PCC deficiency is a rare autosomal recessive metabolic
  • Propionyl coenzyme A carboxylase may refer to: Methylmalonyl - CoA decarboxylase, an enzyme Propionyl - CoA carboxylase an enzyme
  • 3 - methylcrotonyl CoA The MCC holoenzyme is thought to be a heterododecamer 6α6β with close structural analogy to propionyl - CoA carboxylase PCC another
  • S - methylmalonyl - CoA carboxy - lyase propanoyl - CoA - forming Other names in common use include propionyl - CoA carboxylase propionyl coenzyme A carboxylase methylmalonyl - coenzyme
  • Methylmalonyl - CoA is formed from propionyl - CoA by propionyl - CoA carboxylase by help of biotin vitamin B7 It is converted into succinyl - CoA by methylmalonyl - CoA mutase
  • mitochondria propionyl - CoA carboxylase with biotin as a cofactor to produce S - methylmalonyl - CoA This is subsequently converted to R - methylmalonyl - CoA by mitochondrial
  • In this pathway CO 2 is fixed i.e. incorporated by the action of two enzymes, acetyl - CoA carboxylase and propionyl - CoA carboxylase These enzymes generate
  • S - methylmalonyl - CoA by the enzyme Propionyl - CoA carboxylase Methylmalonyl CoA epimerase then catalyzes the rearrangement of S - methylmalonyl - CoA to the R
  • first is Propionyl - Coa Cabroxylase. This enzyme is responsible for carboxylating the α - carbon of a Propionyl - CoA to produce D - methylmalonyl - CoA After this
  • 1: pyruvate carboxylase EC 6.4.1.2: acetyl - CoA carboxylase EC 6.4.1.3: propionyl - CoA carboxylase EC 6.4.1.4: methylcrotonoyl - CoA carboxylase EC 6.4.1.5:
  • complex concentrate, a medication Propionyl - CoA carboxylase catalyses the carboxylation reaction of propionyl CoA in the mitochondrial matrix