ⓘ CLIP (protein)


ⓘ CLIP (protein)

CLIP or Class II-associated invariant chain peptide is the part of the invariant chain that binds MHC class II groove and remains there until the MHC receptor is fully assembled. The purpose of CLIP is to prevent the binding of self-peptide fragments prior to MHC II localization within the endo/lysosome.

When assembling the second MHC, invariant chain complexes with the complex of MHC II class. In special the endosome, the second compartment called the MHC, cathepsin s cleaves the invariant chain leaving clip associated with the MHC complex is class II. In the presence of fragments of the antigen peptide, HLA-DM, then binds to MHC II, releasing clip and allowing peptides to bind. MHC II-bound antigen is transported to the cell membrane for presentation. HLA-cannot obstruct the reaction is catalyzed by HLA-DM.

The clip plays a role in myeloid leukemia.


  • Clip or CLIP may refer to: Clip refers to several types of fasteners: Hair clip a device used to hold hair together or attaching materials such as caps
  • immunoprecipitation HITS - CLIP also known as CLIP - Seq is a genome - wide means of mapping protein RNA binding sites or RNA modification sites in vivo. HITS - CLIP was originally
  • CAP - GLY domain containing linker protein 1, also known as CLIP 1, is a protein which in humans is encoded by the CLIP 1 gene. CLIP 1 has been shown to interact
  • binding proteins RBPs from large - scale CLIP - Seq HITS - CLIP PAR - CLIP i CLIP CLASH datasets. RBPDB database: a database of RNA binding proteins ATtRACt
  • immunoprecipitation CLIP is a method used in molecular biology that combines UV cross - linking with immunoprecipitation in order to analyse protein interactions
  • CAP - Gly domain - containing linker protein 2 is a protein that in humans is encoded by the CLIP 2 gene. The protein encoded by this gene belongs to the family
  • microtubule plus - end trafficking proteins TIPs have been discovered since the first finding of TIP CLIP - 170 CLIP 1 in 1999. Since then TIPs have
  • complexes at high resolution. CLIP - Seq, a similar method for identifying the binding sites of cellular RNA - binding proteins RBPs or RNA modification sites
  • In cell biology, microtubule - associated proteins MAPs are proteins that interact with the microtubules of the cellular cytoskeleton. MAPs bind to the
  • derivatives CLIP - tag, a mutated eukaryotic DNA methyltransferase that covalently attaches to benzylcytosine derivatives Maltose binding protein - tag, a protein which