ⓘ Transporter associated with antigen processing

                                     

ⓘ Transporter associated with antigen processing

Transporter associated with antigen processing protein complex belongs to the ATP-binding-cassette transporter family. It delivers cytosolic peptides into the endoplasmic reticulum, where they bind to nascent MHC class I molecules.

The valve design consists of two proteins: tap 1 and tap 2, which have one hydrophobic region and one ATP-binding friend. They gather in a heterodimer, which results in a four-domain Transporter.

                                     
  • Transporter associated with Antigen Processing 1 is a protein that in humans is encoded by the TAP1 gene. The membrane - associated protein encoded by this
  • ER via the action of heat shock proteins and the transporter associated with antigen processing TAP which translocates the cytosolic peptides into
  • class I molecules and the transporter associated with antigen processing TAP which is required for the transport of antigenic peptides across the endoplasmic
  • Antigen processing or the cytosolic pathway, is an immunological process that prepares antigens for presentation to special cells of the immune system
  • Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing EMBO J. 20 17 4964 72. doi: 10.1093 emboj 20.17
  • Suita N, Maeda M 2003 Gene organization of human transporter associated with antigen processing - like TAPL, ABCB9 analysis of alternative splicing
  • Membrane - associated transporter protein MATP also known as solute carrier family 45 member 2 SLC45A2 or melanoma antigen AIM1, is a protein that in
  • TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2. The membrane - associated protein encoded by this gene is a member of the
  • Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing The EMBO Journal. 20 17 4964 72. doi: 10.1093 emboj 20
  • Some of these antigens are ubiquitiouly expressed in nucleated male cells, and the presence of these antigens has been associated with a greater risk