ⓘ Cholesterol side-chain cleavage enzyme

                                     

ⓘ Cholesterol side-chain cleavage enzyme

Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. P450scc is a mitochondrial enzyme that catalyzes conversion of cholesterol to pregnenolone. This is the first reaction in the process of steroidogenesis in all mammalian tissues that specialize in the production of various steroid hormones.

P450scc is a member of the superfamily of cytochrome P450 enzymes. The Gene name is CYP11A1.

                                     
  • 22 - desmolase, but now identified as cytochrome P450scc cholesterol side chain cleavage enzyme However, few cases of lipoid CAH due to a mutation and
  • Examples of desmolases are: Cholesterol side - chain cleavage enzyme also called 20, 22 - desmolase converts cholesterol to pregnenolone. 17, 20 - Desmolase
  • steroid hormones from cholesterol Cholesterol 3β - cholest - 5 - en - 3 - ol is hydroxylated by cholesterol side - chain cleavage enzyme P450scc to form
  • steroid hormones from cholesterol Cholesterol 3β - cholest - 5 - en - 3 - ol is hydroxylated by cholesterol side - chain cleavage enzyme P450scc to form
  • Levoketoconazole has also been found to inhibit CYP11A1 cholesterol side - chain cleavage enzyme and CYP51A1 lanosterol - 14α - demethylase similarly but
  • present in other tissues in the body. Steroid desmolases Cholesterol side - chain cleavage enzyme 20, 22 - desmolase steroid synthesis 17, 20 - Lyase 17, 20 - desmolase
  • 21 - hydroxylase, and 3β - hydroxysteroid dehydrogenase, as well as of cholesterol side - chain cleavage enzyme thereby inhibiting the production of steroid hormones including
  • inhibitor of the adrenal cortex. It acts as an inhibitor of cholesterol side - chain cleavage enzyme P450scc, CYP11A1 and also of 11β - hydroxylase CYP11B1
  • enzymes such as cholesterol side - chain cleavage enzyme CYP11A1, P450scc and aromatase CYP19A1 thereby inhibiting the conversion of cholesterol into
  • cholesterol contributes to the fluidity of the cell membrane, as the molecule is in a trans conformation making all but the side chain of cholesterol
  • spironolactone, canrenone inhibits steroidogenic enzymes such as 11β - hydroxylase, cholesterol side - chain cleavage enzyme 17α - hydroxylase, 17, 20 - lyase, and 21 - hydroxylase