ⓘ Geranylgeranyltransferase type 1

                                     

ⓘ Geranylgeranyltransferase type 1

Geranylgeranyltransferase type 1 or simply geranylgeranyltransferase is one of the three enzymes in the prenyltransferase group. In specific terms, Geranylgeranyltransferase adds a 20-carbon isoprenoid called a geranylgeranyl group to proteins bearing a CaaX motif: a four-amino acid sequence at the carboxyl terminal of a protein. Geranylgeranyltransferase inhibitors are being investigated as anti-cancer agents.

                                     
  • Rab geranylgeranyltransferase also known as geranylgeranyltransferase II is one of the three prenyltransferases. It transfers usually two geranylgeranyl
  • Protein geranylgeranyltransferase type I subunit beta is a protein that in humans is encoded by the PGGT 1 B gene. Protein geranylgeranyltransferase type I GGTase - I
  • In enzymology, a protein geranylgeranyltransferase type I EC 2.5. 1 59 is an enzyme that catalyzes the chemical reaction geranylgeranyl diphosphate
  • In enzymology, a protein geranylgeranyltransferase type II EC 2.5. 1 60 is an enzyme that catalyzes the chemical reaction geranylgeranyl diphosphate
  • Protein farnesyltransferase geranylgeranyltransferase type - 1 subunit alpha is an enzyme that in humans is encoded by the FNTA gene. Prenyltransferases
  • Geranylgeranyltransferase type 1 also referred to as geranylgeranyltranferase 1 or just geranylgeranyltranferase Prenylation Rab geranylgeranyltransferase Geranylgeranyltransferase
  • compound, PTX - 100, blocks a cancer growth enzyme known as geranylgeranyltransferase type 1 GGT - I PTX - 200 is in a Phase Ib II trial in breast cancer
  • interactions and protein membrane interactions. Farnesyltransferase and geranylgeranyltransferase I are very similar proteins. They consist of two subunits, the
  • P.J. Beese, L.S. 2003 Structure of mammalian protein geranylgeranyltransferase type - 1 EMBO J. 22 22 5963 5974. doi: 10.1093 emboj cdg571. PMC 275430
  • geranylgeranylated on its sn - 3 position by a cytosolic enzyme, phosphoglycerol geranylgeranyltransferase and another geranylgeranyl group is then added on the sn - 2 position
  • Rab escort protein 1 REP 1 also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene