ⓘ RNF144A

                                     

ⓘ RNF144A

RNF144A is an E3 ubiquitin ligase belonging to the RING-between RING family of ubiquitin ligases, whose specific members have been shown to function as RING-HECT hybrid E3 ligases. RNF144A is most closely related to RNF144B at the protein level, and the two proteins together comprise a subdomain within the RBR family of proteins. The ubiquitin ligase activity of RNF144A catalyzes ubiquitin linkages at the K6-, K11- and K48- positions of ubiquitin in vitro, and is regulated by self-association through its transmembrane domain.

Biological function of RNF144A is relatively unknown outside its domestic activity of enzymes. Somatic mutations RNF144A was catalogued in genetic databases cancer in several primary human tumors, including breast, stomach, lymphoma, glioblastoma, uterine and lung cancer. Other members of the RBR family has been associated with neurological and immunological diseases in the first place Parkin, HOIL-1L and HOIPRNF31.

RNF144A known substrates targeted for degradation proteins involved in DNA repair, functions of heatshock / the chaperone and signaling, in accordance with the prevailing Association of this protein with cancer and include DNA-PKCS, PARP1, HSPA2, BMI1, and raf1 which.