ⓘ Natural killer cell enteropathy
Natural killer cell enteropathy, also termed NK cell enteropathy, and a closely related disorder, lymphomatoid gastropathy, are non-malignant diseases in which one type of lymphocyte, the natural killer cell, proliferates excessively in the gastrointestinal tract. This proliferation causes red, sore-like spots, raised lesions, erosions, and ulcers in the mucosal layer surrounding the GI tract lumen. Both disorders cause either no or only vague symptoms of GI tract disturbances such as nausea, vomiting, and bleeding.
In 2006, the persistent, but apparently benign disease, which is involved in the proliferation of NK cells in various locations throughout the intestine have been described. This disorder appeared similar and easily mistaken for a very malignant disease, extranodal NK / T-cell lymphoma, nasal type. In 2010 has been described as a benign disease, which is involved in the proliferation of NK cells in the stomach. Diseases of the gastrointestinal tract mimicked lymphoma. Since these early descriptions, several case series and reports were published on these enteropathies.
These two diseases proliferation of NK was named NK-cell lymphomatoid gastropathy and enteropathy with NKCE is considered mainly in the United States and in Korea and LG is seen mostly in Japan. Besides this geographical difference, the only other important difference between these two diseases is that defeat in the NKCE occur in the small intestine, colon, stomach and / or esophagus, whereas the LH is limited to the abdomen. Because the pathophysiological features of these two diseases are almost identical, NKCE and LG is now generally regarded as manifestations of the same disease.
Only 36 patients with NKCE or LG has not been received as of January 2019. However, these diseases have become important clinical entities because they 1) were recently described and probably are diagnosed more often because they have become better known and 2) were adopted, and referred to as different types of premalignant and malignant lymphomas of the gastrointestinal tract. Given the radical differences in the forecasts and treatment NKCE and LG compared with the lymphomas they can mimic the evaluation of many lymphocyte-proliferative disorders of the gastrointestinal tract must be considered and ruled out that they NKCE or LG, and not a pre-cancerous disease or a malignant lymphoma.
- Enteropathy - associated T - cell lymphoma EATL previously termed enteropathy - associated T - cell lymphoma, type I and at one time termed enteropathy - type
- Angioimmunoblastic T - cell lymphoma Extranodal natural killer T - cell lymphoma, nasal type Enteropathy type T - cell lymphoma Subcutaneous panniculitis - like T - cell lymphoma
- proliferation of non - malignant NK cells in the GI tract viz., Natural killer cell enteropathy a disease wherein NK cell infiltrative lesions occur in the
- intestinal T cell lymphoma MEITL formerly termed enteropathy - associated T cell lymphoma, type II is an extremely rare peripheral T - cell lymphoma that
- can be further classified as T cells B cells and natural killer cells Neutrophils are the most abundant white blood cell constituting 60 - 70 of the circulating
- proliferation of the primary cells of the immune system, which includes B cells T cells and natural killer NK cells or by the excessive production
- and ulcerative colitis should point to the proper diagnosis. Natural killer cell enteropathy NKCE NKCE is an indolent disease in which lymphocytes proliferate
- proliferation of non - malignant NK cells in the GI tract, natural killer cell enteropathy a disease wherein NK cell infiltrative lesions occur in the
- cancer development and progression, or become the malignant cells in enteropathy - associated T - cell lymphoma, a lymphoma that is a complication of celiac sprue
- syndrome type 1 APS - 1 and immunodysregulation polyendocrinopathy enteropathy X - linked syndrome IPEX and potentially contribute to asthma, allergy