ⓘ Hexosaminidase

                                     

ⓘ Hexosaminidase

Hexosaminidase is an enzyme involved in the hydrolysis of terminal N-acetyl-D-hexosamine residues in N-acetyl-β-D-hexosaminides.

                                     
  • disorder caused by the inherited deficiency to create functional beta - hexosaminidases A and B. These catabolic enzymes are needed to degrade the neuronal
  • Beta - hexosaminidase subunit beta is an enzyme that in humans is encoded by the HEXB gene. Hexosaminidase B is the beta subunit of the lysosomal enzyme
  • Hexosaminidase A alpha polypeptide also known as HEXA, is an enzyme that in humans is encoded by the HEXA gene, located on the 15th chromosome. Hexosaminidase
  • same enzyme, beta - hexosaminidase AB variant is caused by a failure in the gene that makes an enzyme cofactor for beta - hexosaminidase called the GM2 activator
  • manner. The mutation results in problems with an enzyme called beta - hexosaminidase A which results in the buildup of the molecule GM2 ganglioside within
  • are 3 forms of beta - hexosaminidase hexosaminidase A is a trimer, with one alpha, one beta - A and one beta - B chain hexosaminidase B is a tetramer of two
  • individual names. Beta - hexosaminidase is a vital hydrolytic enzyme, found in the lysosomes, that breaks down lipids. When beta - hexosaminidase is no longer functioning
  • N - terminal domain represents the N - terminal domain in chitobiases and beta - hexosaminidases Chitobiases degrade chitin, which forms the exoskeleton in insects
  • substrate 4 - nitrophenyl N - acetyl - β - D - glucosamine. Dispersin B is a β - hexosaminidase that specifically hydrolyzes β - 1, 6 - glycosidic linkages of acetylglucosamine