ⓘ Zonadhesin

                                     

ⓘ Zonadhesin

This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition.

Allelic polymorphism, the gene as a functional and frameshifted allele reference genome represents the functional allele. Alternative splicing of this gene will lead to the emergence of several variants of decoding.

                                     
  • are necessary for multimerisation. This domain is found in mucins, in zonadhesin in otogelin, and in vitellogenin. Many of these proteins are extracellular
  • PMID 9949200. Alloisio N, Morle L, Bozon M, et al. 1999 Mutation in the zonadhesin - like domain of alpha - tectorin associated with autosomal dominant non - syndromic