ⓘ Phosphatidylserine synthase 1

                                     

ⓘ Phosphatidylserine synthase 1

The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine synthase localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene.

                                     
  • phosphatidyltransferase EC 2.7.8.29, phosphatidylserine synthase 2, serine - exchange enzyme II, PTDSS2 gene is an enzyme with systematic name L - 1 - phosphatidylethanolamine: L - serine
  • overactive phosphatidylserine synthase 1 was the cause of LMS, making it the first known human disease to be caused by disrupted phosphatidylserine metabolism
  • common use include phosphatidylserine synthase CDPdiglyceride - serine O - phosphatidyltransferase, PS synthase cytidine 5 - diphospho - 1 2 - diacyl - sn - glycerol
  • synthase kinase 3 β GSK - 3β In the same study administration of proadifen was demonstrated to produce time - and dose - dependent phosphatidylserine externalization
  • studies show that PLSCR 1 is neither sufficient nor necessary for the phosphatidylserine externalization, the involvement of PLSCR 1 in blood coagulation
  • contains a putative regulatory gene, crdR. A membrane - bound phosphatidylserine synthase encoded by pssAG, is also necessary for maximal production of
  • 1.1.65: phosphatidylserine decarboxylase EC 4. 1 1 66: uracil - 5 - carboxylate decarboxylase EC 4. 1 1 67: UDP - galacturonate decarboxylase EC 4. 1 1 68: 5 - oxopent - 3 - ene - 1
  • Lenz - Majewski syndrome which is due to a mutation in the phosphatidylserine synthase 1 PTDSS 1 gene. In contrast, acquired cutis laxa often has a triggering
  • response gene SDPR maps to 2q32 - q33 and codes for a phosphatidylserine - binding protein Genomics. 57 1 120 9. doi: 10.1006 geno.1998.5733. PMID 10191091
  • which transform phosphatidic acid PA into phosphatidylserine PS by phosphatidylserine synthases 1 and 2 PSS 1 PSS2 in the ER and then transfers PS to