ⓘ B cell scaffold protein with ankyrin repeats 1

                                     

ⓘ B cell scaffold protein with ankyrin repeats 1

The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1.4.5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.

                                     
  • Bank 1 B - cell scaffold protein with ankyrin repeats 1 is a protein - encoding human gene located on chromosome 4 4q24. Adaptor protein that binds the proteins
  • ankyrin repeat proteins are genetically engineered antibody mimetic proteins typically exhibiting highly specific and high - affinity target protein binding
  • multiple ankyrin repeat domains protein 1 is a protein that in humans is encoded by the SHANK 1 gene. SHANK 1 has been shown to interact with ARHGEF7
  • SH3 and multiple ankyrin repeat domains 3 Shank3 also known as proline - rich synapse - associated protein 2 ProSAP2 is a protein that in humans is encoded
  • D - interacting substrate of 220 kDa or ARMS ankyrin repeat - rich membrane spanning is a scaffold protein that in humans is encoded by the KIDINS220 gene
  • SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. Two alternative splice variants, encoding
  • inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein - protein interactions. Mutations in this gene have been
  • repeats, including HEAT repeats Armadillo repeats tetratricopeptide TPR repeats leucine - rich repeats and ankyrin repeats Alpha solenoids have unusual
  • with protein 4. 1 and ankyrin with the transmembrane ion transporter band 3 Protein 4.2 binds the spectrin tail region to the transmembrane protein glycophorin
  • alternative scaffold for binding proteins antibody mimetics DARPins are derived from naturally occurring ankyrin proteins a protein class that mediates
  • called ankyrin repeats By virtue of their ankyrin repeat domains, the Iκ B proteins mask the nuclear localization signals NLS of NF - κ B proteins and keep
  • demonstrated that plakophilin - 2 associates with an important component of the Na V 1 5 complex, ankyrin G, and loss of ankyrin G via siRNA downregulation mislocalized