ⓘ YTHDF2

                                     

ⓘ YTHDF2

This gene encodes a member of the YTH YT521-B homology superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline-rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. Also, reciprocal translocations between this gene and the Runx1 AML1 gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively, spliced transcript variants encoding different isoforms have been identified in this gene.

                                     
  • YTH domain family, member 1 is a protein that in humans is encoded by the YTHDF 1 gene. N6 - Methyladenosine GRCh38: Ensembl release 89: ENSG00000149658
  • readers. The YT521 - B homology YTH domain family of proteins YTHDF 1, YTHDF2 YTHDF 3 and YTHDC1 have been characterized as direct m6A readers and have
  • proteins have higher binding affinities to methylated mRNA. The YTH protein YTHDF2 affects mRNA by directing methylated mRNA from the translational pool to
  • protein B and C YTHDF 1: encoding protein YTH domain family, member 1 ZFP64 encoding protein Zinc finger protein 64 homolog, isoforms 1 and 2 ZGPAT: encoding
  • syndrome YTHDF 3: YTH N6 - methyladenosine RNA binding protein 3 ZFP41: encoding protein ZFP41 zinc finger protein ZHX 2 zinc fingers and homeoboxes protein 2 ZMAT4: