ⓘ Alpha-2-Macroglobulin

                                     

ⓘ Alpha-2-Macroglobulin

alpha-2-Macroglobulin is a large plasma protein found in the blood. It is mainly produced by the liver, and also locally synthesized by macrophages, fibroblasts, and adrenocortical cells. In humans it is encoded by the A2M gene.

Alpha 2 macroglobulin acts as an antiprotease and is able in inactivate a huge variety of proteinases. It acts as an inhibitor of fibrinolysis by inhibiting plasmin and kallikrein. It acts as an inhibitor of coagulation by inhibiting thrombin. Alpha-2-macroglobulin may act as a carrier protein because it also binds various growth factors and cytokines such as platelet derived growth factor, basic fibroblast growth factor, TGF-β, insulin, and Il-1β.

No specific deficiency with associated disease has been recognized, no state of disease is due to a low concentration of alpha-2-macroglobulin. The concentration of alpha-2-macroglobulin rises 10 times or more in the nephrotic syndrome when other lower molecular weight proteins are lost in urine. The loss of alpha-2-macroglobulin in the urine hinders its large size. The net result is that alpha-2-macroglobulin in the serum reaches a level equal to or greater than that of albumin in nephrotic syndrome, which has the effect of maintaining oncotic pressure.

                                     
  • when temperature drops as in cryoglobulinaemia Other macroglobulins include alpha - 2 macroglobulin which is elevated in nephrotic syndrome, diabetes, severe
  • Alpha - 2 - macroglobulin - like 1 abbreviated as α 2 ML1 is a protein that in humans is encoded by the A 2 ML1 gene. α 2 ML1 is a large, 180 kDa protein found in
  • include the following: α 2 - pregnoglobulin, pregnancy - associated α 2 - glycoprotein, α - acute - phase glycoprotein, alpha - 2 - macroglobulin like, Xh - antigen
  • A Alpha 1 - lipoprotein Haptoglobin Alpha - 2 u globulin α 2 - macroglobulin Ceruloplasmin Thyroxine - binding globulin Alpha 2 - antiplasmin Protein C Alpha 2 - lipoprotein
  • A 2 M may refer to: Alpha - 2 - Macroglobulin a gene with the ability to inhibit all four classes of proteinases by a unique trapping mechanism Artificial
  • LDL receptor family including LRP1 and LRP 2 It is a glycoprotein that binds to the alpha - 2 - macroglobulin receptor, as well as to other members of the
  • by filtering blood to remove some components such as fibrinogen, alpha - 2 - macroglobulin von Willebrand factor, LDL cholesterol and immunoglobulin M. It
  • haptoglobin as seen in the alpha - 2 beta interzone. This is typically seen as a broadening of the alpha - 2 zone. Alpha - 2 macroglobulin may be elevated in children
  • ISBN 978 - 0 - 7817 - 9543 - 2 Page 182 de Boer JP, Creasey AA, Chang A, Abbink JJ, Roem D, Eerenberg AJ, et al. December 1993 Alpha - 2 - macroglobulin functions as
  • lipoprotein receptor - related protein 1 LRP1 also known as alpha - 2 - macroglobulin receptor A 2 MR apolipoprotein E receptor APOER or cluster of differentiation
  • alpha - 2 - macroglobulin These discoveries may link alpha - 2 - macroglobulin and its receptors, one of them being ApoER 2 to Alzheimer s disease. ApoER 2 interaction