ⓘ Cytokine dependent hematopoietic cell linker

                                     

ⓘ Cytokine dependent hematopoietic cell linker

MIST is a member of the SLP76 family of adaptors. MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma PLCG1, MIM 172420-mediated B cell antigen receptor BCR signaling and FC-epsilon R1 see FCER1A, MIM 147140-mediated mast cell degranulation Cao et al., 1999.

                                     
  • Hematopoietic stem cells HSCs are the stem cells that give rise to other blood cells This process is called haematopoiesis. This process occurs in the
  • Cytokines are a broad and loose category of small proteins 5 20 kDa that are important in cell signaling. Cytokines are peptides, and cannot cross the
  • Additionally, B cells present antigen they are also classified as professional antigen - presenting cells APCs and secrete cytokines In mammals, B cells mature
  • has been shown that the two cells develop from different hematopoietic lineages and thus cannot be the same cells Mast cells are very similar to basophil
  • viral oncogene v - kit. KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this
  • JNK1 in hematopoietically derived cells contributes to diet - induced inflammation and insulin resistance without affecting obesity Cell Metabolism
  • and a beta chain. Some TCRs have a gamma and a delta chain. Hematopoietic stem cells in the bone marrow migrate into the thymus, where they undergo
  • common gamma chain γc As JAK3 is expressed in hematopoietic and epithelial cells its role in cytokine signaling is thought to be more restricted than
  • to cells matured from monocytes. HP - DC refers to cells derived from hematopoietic progenitor cells Dendritic cells are derived from hematopoietic bone
  • as stem cell regulators. TGFβ The TGFβ family of cytokines regulate the stemness of both normal and cancer stem cells Hematopoietic stem cells HSCs
  • Thymocytes are hematopoietic progenitor cells present in the thymus. Thymopoiesis is the process in the thymus by which thymocytes differentiate into mature