ⓘ Chromatin accessibility complex 1

                                     

ⓘ Chromatin accessibility complex 1

CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.

                                     
  • Chromatin is a complex of DNA and protein found in eukaryotic cells. Its primary function is packaging long DNA molecules into a more compact, denser structures
  • greater chromatin accessibility General loss of methylation, combined with the addition of acetyl groups results in a more accessible chromatin conformation
  • increase in transcription. The protein interactions of the SWI SNF complex with the chromatin allows binding of transcription factors and therefore increase
  • CAF - 1 chromatin assembly factor - 1 is a complex including Chaf 1 a p150 Chaf 1 b p60 and p50 subunits that assembles histone tetramers onto replicating
  • Transcription activator BRG 1 also known as ATP - dependent chromatin remodeler SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene. The protein
  • regulates gene expression through chromatin remodeling by the NURF complex This makes the DNA in the chromatin more accessible for transcription factors, allowing
  • addition to nucleosome wrapping, eukaryotic chromatin is further compacted by being folded into a series of more complex structures, eventually forming a chromosome
  • preferences for the two isoforms. NF - Y complex serves as a pioneer factor by promoting chromatin accessibility to facilitate other co - localizing cell
  • ATAC - seq: A Method for Assaying Chromatin Accessibility Genome - Wide Current Protocols in Molecular Biology. 109: 21.29. 1 21.29.9. doi: 10.1002 0471142727