ⓘ MicroRNA 486-1

                                     

ⓘ MicroRNA 486-1

microRNAs miRNAs are short 20-24 nt non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts pri-miRNAs that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA pre-miRNA, which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star miRNA* products. The mature miRNA is incorporated into a RNA-induced silencing complex RISC, which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

                                     
  • A microRNA abbreviated mi RNA is a small non - coding RNA molecule containing about 22 nucleotides found in plants, animals and some viruses, that functions
  • The miR - 1 microRNA precursor is a small micro RNA that regulates its target protein s expression in the cell. micro RNAs are transcribed as 70 nucleotide
  • by several pre - and post - transcription mechanisms. Mir - 126 is a human microRNA that is expressed only in endothelial cells, throughout capillaries as
  • miR - 224 is a family of microRNA precursors found in mammals, including humans. The 22 nucleotide mature mi RNA sequence is excised from the precursor
  • Darnell, R.B. 2009 Argonaute HITS - CLIP decodes microRNA - m RNA interaction maps Nature, 460 7254 479 486 doi: 10.1038 nature08170, PMC 2733940, PMID 19536157
  • not as naked RNAs These non - coding RNAs include micro RNAs small interfering RNAs si RNA as well as splicesomal small nuclear RNAs sn RNA Alternative
  • MiR - 206 is a microRNA that in humans is a member of the myomiR family which also includes miR - 1 miR - 133, miR - 208a b among few others. As well as being
  • m RNA decay, nonsense - mediated m RNA decay, adenylate - uridylate - rich element mediated m RNA decay, and microRNA induced m RNA silencing. Not all m RNAs which
  • complementary codon on m RNA and abbreviated t RNA and formerly referred to as s RNA for soluble RNA is an adaptor molecule composed of RNA typically 76 to
  • Darnell, RB 2009 Argonaute HITS - CLIP decodes microRNA - m RNA interaction maps Nature. 460 7254 479 486 doi: 10.1038 nature08170. PMC 2733940. PMID 19536157
  • oligonucleotides are usually found as small RNA molecules that function in the regulation of gene expression e.g. microRNA or are degradation intermediates