ⓘ CYP2C19

                                     

ⓘ CYP2C19

Cytochrome P450 2C19 is an enzyme. This protein, a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics, including many proton pump inhibitors and antiepileptics. In humans, the CYP2C19 protein is encoded by the CYP2C19 gene. CYP2C19 is a liver enzyme that acts on at least 10% of drugs in current clinical use, most notably the antiplatelet treatment clopidogrel also drugs that treat pain associated with ulcers, such as omeprazole, antiseizure drugs such as mephenytoin, the antimalarial proguanil, and the anxiolytic diazepam.

СУР2С19 was annotated as R-limonene 6-monooxygenase and the S-limonene 6-monooxygenase in so.

                                     
  • products that act as signaling molecules. It along with CYP 2 C 8, CYP2C19 CYP 2 J 2 and possibly CYP 2 S1 are the principle enzymes which metabolizes 1 arachidonic
  • additional gene, CYP 2 C 17, was once thought to exist however, CYP 4217 is now considered an artefact based on a chimera of CYP 2 C 18 and CYP2C19 CYP 2 C 18 also possesses
  • epoxyeicosatetraenoic acids also termed EEQs Along with CYP 2 C 8, CYP 2 C 9, CYP2C19 CYP 2 J 2 and possibly CYP 2 S1 are the main producers of EETs and, very likely
  • FC, Longtine JA, Jarolim P December 2010 Allelic variations in CYP 2 B6 and CYP2C19 and survival of patients receiving cyclophosphamide prior to myeloablative
  • for CYP 2 A6 activity. The CYP 2 A6 gene is part of a large cluster of cytochrome P450 genes from the CYP 2 A, CYP 2 B and CYP 2 F subfamilies on chromosome 19 q.
  • cytochrome P450 enzymes: 2 D6 and 2 C 19 CYP 2 D6 and CYP2C19 belong to the Cytochrome P450 oxidase family. CYP 2 D6 has over 90 variants, 2 C 19 has mainly three. They
  • e. DHA to epoxydocosapentaenoic acids i.e. EDPs CYP 2 C 8, CYP 2 C 9, CYP 2 C 18, CYP2C19 and CYP 2 J 2 metabolize endogenous PUFAs to signaling molecules: they
  • Cytochrome P450 2 D6 CYP 2 D6 is an enzyme that in humans is encoded by the CYP 2 D6 gene. CYP 2 D6 is primarily expressed in the liver. It is also highly expressed
  • a minor metabolic pathway via CYP2C19 - dependent hydroxylation. Individuals who have no CYP2C19 enzyme activity, CYP2C19 poor metabolizers will have
  • EPAs and EEQs are: 1 more potent than the CYP 450 epoxygenase e.g. CYP 2 C 8, CYP 2 C 9, CYP2C19 CYP 2 J 2 and CYP 2 S1 - formed epoxides of arachidonic acid termed
  • metabolized by the hepatic enzyme CYP2C19 Some individuals, such as people of Japanese ancestry, are more likely to be poor CYP2C19 metabolizers that is, their