ⓘ Carotenosis

                                     

ⓘ Carotenoderma

Carotenosis is a benign and reversible medical condition where an excess of dietary carotenoids results in orange discoloration of the outermost skin layer. The discoloration is most easily observed in light-skinned people and may be mistaken for jaundice. Carotenoids are lipid-soluble compounds that include alpha- and beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin. The primary serum carotenoids are beta-carotene, lycopene, and lutein. Serum levels of carotenoids vary between region, ethnicity, and sex in the healthy population. All are absorbed by passive diffusion from the gastrointestinal tract and are then partially metabolized in the intestinal mucosa and liver to vitamin A. From there they are transported in the plasma into the peripheral tissues. Carotenoids are eliminated via sweat, sebum, urine, and gastrointestinal secretions. Carotenoids contribute to normal-appearing human skin color, and are a significant component of physiologic ultraviolet photoprotection.

Carotenemia is most often occurs in vegetarians and young children. Carotenemia is more easily appreciated in the bright man, and he may present mainly as the orange coloring of the palms and soles in more darkly pigmented people. Carotenemia does not cause selective orange conjunctival shell over the sclera whites of the eyes, and thus is usually easy to distinguish from the yellowing of the skin and conjunctiva, caused by bile pigments in States of jaundice.

Carotenoderma is deliberately caused by beta-carotenoid treatment of certain photo-sensitive diseases, such as dermatitis, erythropoietic protoporphyria, where beta carotene in quantities which discolor the skin. These high doses of beta-carotene, proved to be harmless in studies, although cosmetically unpleasant for some. In a recent meta-analysis of these treatments, however, the effectiveness of the treatment was questioned.

                                     
  • longstanding disease. Conditions included in this group are: Acral dry gangrene Carotenosis Diabetic dermopathy Diabetic bulla Diabetic cheiroarthropathy Malum perforans
  • fruits and berries, which leads to a reddish discoloration of the skin. Carotenosis Skin lesion James, William Berger, Timothy Elston, Dirk 2005 Andrews
  • Tapuz or Tapuz Anashim Hebrew: Orange People an Israeli Web portal Carotenosis a disease that causes orange skin color List of people from Orange County
  • Dyschromia Erythrism Heterochromia iridum Leucism Melanism Piebaldism Carotenosis Cornell University Project Feeder Watch 2002 - 2003 Accessed 19 March 2007