ⓘ Artificial antigen presenting cells

                                     

ⓘ Artificial antigen presenting cells

Artificial antigen presenting cells are a new technology and approach to cancer immunotherapy. Immunotherapy aims to utilize the body’s own defense mechanism - the immune system - to recognize mutated cancer cells and to kill them the way the immune system would recognize and kill a virus. Antigen presenting cells are the sentinels of the immune system and patrol the body for pathogens. When they encounter foreign pathogens, the antigen presenting cells alert the T cells -" the soldiers of the immune system” - that there is something foreign in the body with specific cell surface molecules. aAPCs are synthetic versions of these sentinel cells and are made by attaching the specific T-cell stimulating signals to various macro and micro biocompatible surfaces. This can potentially reduce the cost while allowing control over generating large numbers of functional pathogen-specific T cells for therapy. Activated and stimulated T cells can be studied in this biomimetic contex and used for adoptive transfer as an immunotherapy.

                                     
  • involve the creation of artificial APCs to prime the adaptive immune system to target malignant cells Antigen - presenting cells fall into two categories:
  • Chimeric antigen receptor T cells also known as CAR T cells are T cells that have been genetically engineered to produce an artificial T - cell receptor
  • automobile trade group of Ford, Chrysler, and General Motors Artificial antigen presenting cells Association des architectes paysagistes du Canada Canadian
  • the cell These cells were micron - sized and contained cell enzymes, hemoglobin, magnetic materials, adsorbents and proteins. Later artificial cells have
  • by antigen - presenting cells Co - stimulation of the B cell by activated T cell resulting in its complete activation. Proliferation of B cells with resultant
  • where selection is inspired by the affinity of antigen - antibody interactions, reproduction is inspired by cell division, and variation is inspired by somatic
  • activated dendritic cell With the exception of non - nucleated cells including erythrocytes all cells are capable of presenting antigen through the function
  • upon T cell activation, and TGF - β from any of a variety of sources, including tolerizing dendritic cells DCs other antigen presenting cells or in
  • and antigens depend more on their shape than their chemical composition. In 1948, Astrid Fagreaus discovered that B cells in the form of plasma cells were
  • recognizing an antigen present on normal cells of the organism. This enables the T cells to eliminate cells with foreign or abnormal antigens without harming