ⓘ Antibody-dependent cellular cytotoxicity

                                     

ⓘ Antibody-dependent cellular cytotoxicity

Antibody-dependent cellular cytotoxicity, also referred to as antibody-dependent cell-mediated cytotoxicity, is a mechanism of cell-mediated immune defense whereby an effector cell of the immune system actively lyses a target cell, whose membrane-surface antigens have been bound by specific antibodies. It is one of the mechanisms through which antibodies, as part of the humoral immune response, can act to limit and contain infection.

ASCC is independent of the immune complement system, which is also the goal, but does not require any other cells. ASCC requires effector cells, which classically is considered to be natural killer NK cells, which normally interact with antibodies of the immunoglobulin G immunoglobulin. However, macrophages, neutrophils and eosinophils can also mediate ASKS such as eosinophils to kill certain parasitic worms known as helminths through IgE antibodies.

ASCC is part of the adaptive immune response due to its dependence on prior immunological response. The coating of target cells with antibodies is sometimes called opsonization.

                                     
  • Baeuerle, P A Da Silva, A J 2005 Cellular and complement - dependent cytotoxicity of Ep - CAM - specific monoclonal antibody MT201 against breast cancer cell
  • When antibodies are afucosylated the effect is to increase antibody - dependent cellular cytotoxicity ADCC Most approved monoclonal antibodies are of
  • molecule of the immunoglobulin superfamily IgSF involved in antibody - dependent cellular cytotoxicity ADCC It can be used to isolate populations of specific
  • Complement - dependent cytotoxicity CDC is an effector function of IgG and IgM antibodies When they are bound to surface antigen on target cell e.g.
  • neutralizing antibody or antibody - dependent cellular cytotoxicity - mediating antibodies in the serum contains infection - enhancing antibodies The balance
  • Lymphocyte - mediated cytotoxicity on the other hand, does not have to be mediated by antibodies nor does complement - dependent cytotoxicity CDC which is
  • iodine - 131. Monoclonal antibody therapy Kushner BH, Cheung NK 1989 GM - CSF enhances 3F8 monoclonal antibody - dependent cellular cytotoxicity against human melanoma
  • causes cytotoxicity in the cells that express CD20 by means of complement - dependent cytotoxicity CDC and antibody - dependent cellular cytotoxicity ADCC
  • Plumb D October 1980 Antibody - dependent cellular cytotoxicity in the guinea pig: the role of the Kurloff cell Cellular Immunology. 55 2 312 27
  • regions. The four known IgG subclasses are involved in antibody - dependent cellular cytotoxicity Antibodies are a key component of the adaptive immune response
  • cellular cytotoxicity ADCC as well as complement - dependent cytotoxicity CDC properties. GSK licensed the rights to develop anti - LAG - 3 antibodies for autoimmune
  • causing cells to apoptose via antibody - dependent cellular cytotoxicity or complement - dependent cytotoxicity Encouraging preliminary results were reported