ⓘ Adaptive immunity in jawless fish

                                     

ⓘ Adaptive immunity in jawless fish

Jawless vertebrates, which today consist entirely of lampreys and hagfish, have an adaptive immune system similar to that found in jawed vertebrates. The cells of the agnathan AIS have roles roughly equivalent to those of B-cells and T-cells, with three lymphocyte lineages identified so far:

  • VLRB most similar to B cells.
  • VLRA most similar to α / β T cells.
  • VLRC most similar to γ / δ T cells.

VLRA and VLRB was revealed in 2009, while the VLRC was discovered in 2013. Instead of antibodies, they use variable lymphocyte receptors.