ⓘ Serotonin modulator and stimulator


ⓘ Serotonin modulator and stimulator

A serotonin modulator and stimulator, sometimes referred to more simply as a serotonin modulator, is a type of drug with a multimodal action specific to the serotonin neurotransmitter system. To be precise, SMSs simultaneously modulate one or more serotonin receptors and inhibit the reuptake of serotonin. The term was created to describe the mechanism of action of the serotonergic antidepressant vortioxetine, which acts as a serotonin reuptake inhibitor, agonist of the 5-HT 1A receptor, and antagonist of the 5-HT 3 and 5-HT 7 receptors. However, it can also technically be applied to vilazodone, which is an antidepressant as well and acts as an SRI and 5-HT 1A receptor partial agonist.

SMS was designed because there are many different subtypes of serotonin receptors at least 15 in total at the moment well-known and not all of these receptors appear to participate in the antidepressant effect of Sris. Some of the serotonin receptors seem to play a relatively neutral or marginal role in the regulation of mood, and others such as 5-ht1a autoreceptors and 5-HT 7 receptors, apparently, to play the opposition role in the effectiveness of Sris in the treatment of depression. Thus, a drug that combines the actions of, say, Sri -, 5-ht1a partial agonism, and 5-HT 7 receptor antagonism, theoretically, can be more effective than purely Sris. In addition, antagonism of 5-HT 3 receptors, which are involved in regulation of nausea, vomiting and gastrointestinal tract – can counteract an unwanted increase in the activation of this receptor is mediated by Sris, thereby potentially improving tolerability.

An alternative term is a partial serotonin agonist / reuptake inhibitors sparing that which can only be applied for vilazodone hydrochloride.

Its like a marketing strategy to use for brexpiprazole of the drug, labeling it as "serotonin-dopamine activity modulator" or surrender.

  • 5 - HT2B receptors and an agonist of the 5 - HT1A, 5 - HT2C, and 5 - HT3 receptors. Serotonin modulator and stimulator SMS Noradrenergic and specific serotonergic
  • transporters. Reuptake inhibitor RI Releasing agent RA Serotonin modulator and stimulator SMS another term tentatively created to describe the action
  • ISSN 1176 - 6328. PMC 4844447. PMID 27143896. Lundbeck s Serotonin Modulator and Stimulator Lu AA21004: How Novel? How Good? - GLG News Archived from
  • increased serotonin uptake by circulating platelets and activation after stimulation which gives increased stimulation of myenteric neurons and gastrointestinal
  • preclinical research and may go on to undergo clinical trials. Serotonin antagonist and reuptake inhibitor SARI Serotonin modulator and stimulator SMS Norepinephrine - dopamine
  • disorder SMS gene which encodes the spermine synthase enzyme Serotonin modulator and stimulator a type of drug Synchronous Meteorological Satellite, a program
  • widely used selective serotonin reuptake inhibitors SSRIs which act upon serotonin only. The human serotonin transporter SERT and norepinephrine transporter
  • stabilizer. Trintellix vortioxetine an antidepressant of the serotonin modulator and stimulator class. Tegretol carbamazepine an anticonvulsant used as
  • and vortioxetine Trintellix are SRIs that also act as modulators of serotonin receptors and are described as serotonin modulators and stimulators SMS