ⓘ Surrobody

                                     

ⓘ Surrobody

Based upon the pre-B cell receptor, Surrobodies are non-naturally occurring, antibody-like proteins with high affinity to their antigen. The trimeric pre-BCR composes an antibody heavy chain paired with two surrogate light chain components. They have been generated for both therapeutic and research applications.

Xu et al have generated combinatorial libraries based on these pre-BCR proteins in which different heavy chains paired with a fixed surrogate light chain components. These libraries were expressed in mammalian cells, bacteria, coliform, as well as systems formigny to create proteins with high affinity to its target.

Surrobodies were patented marine biotechnology lane in 2012.