ⓘ P450-containing systems

                                     

ⓘ P450-containing systems

Any enzyme system that includes cytochrome P450 protein or domain can be called a P450-containing system.

P450 enzymes usually act as terminal oxidase in multicomponent electron-transfer chains, called P450-containing monooxygenase systems, although self-contained, monooxygenase P450s have also been described. All known P450-containing monooxygenase systems have common structural and functional domain architecture. In addition to the cytochrome, these systems contain one or more fundamental redox domains: FAD-containing flavoprotein or domain, FMN domain, ferredoxin and cytochrome B 5. These ubiquitous redox domains, in various combinations, are widely distributed in biological systems. FMN domain, ferredoxin or cytochrome B 5 electron transfer between flavin reductase protein or domain and P450. While P450-containing systems are found in all kingdoms of life, some organisms lack one or more of these redox domains.

                                     
  • P450 - containing systems The term P450 is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme 450 nm
  • Cytochrome P450 reductase EC 1.6.2.4 also known as NADPH: ferrihemoprotein oxidoreductase, NADPH: hemoprotein oxidoreductase, NADPH: P 450 oxidoreductase, P450 reductase
  • engineering of cytochrome CYP P450 enzymes. P 450 s are involved in a range of biochemical catabolic and anabolic process. Natural P 450 s can perform several different
  • Cytochrome P450 2E1 abbreviated CYP2E1, EC 1.14.13.n7 is a member of the cytochrome P450 mixed - function oxidase system which is involved in the metabolism
  • Cytochrome P450 1A2 abbreviated CYP1A2 a member of the cytochrome P450 mixed - function oxidase system is involved in the metabolism of xenobiotics in
  • cytochrome P450 enzyme that is involved in the conversion of lanosterol to 4, 4 - dimethylcholesta - 8 9 14, 24 - trien - 3β - ol. The cytochrome P450 isoenzymes
  • ISBN 0 - 8493 - 2983 - 3. Databases Drug metabolism database Directory of P450 - containing Systems University of Minnesota Biocatalysis Biodegradation Database SPORCalc
  • because they share activity profiles similar to those of cytochrome P450 CYP 450 which is the major contributor to oxidative xenobiotic metabolism.
  • Cytochrome P450 3A4 abbreviated CYP3A4 EC 1.14.13.97 is an important enzyme in the body, mainly found in the liver and in the intestine. It oxidizes
  • phase 1 metabolism of amphetamine analogs is catalyzed by two systems cytochrome P450 and flavin monooxygenase. Cashman JR, Xiong YN, Xu L, Janowsky