ⓘ FGF1

                                     

ⓘ FGF1

FGF1, also known as acidic fibroblast growth factor, is a growth factor and signaling protein encoded by the FGF1 gene. It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein. Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1. Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a family of FGF proteins.

FGF-1 has no definitive signal sequence and thus not allocated on the basis of the classical ways, but it seems, forms a disulfide linked dimer within the cells, which is associated with a complex of proteins in the cell membrane, including S100A13 and Syt1 which then help to flip it across the membrane from the external side of the cell. After the decline of the surrounding tissue, the dimer dissociates into the Monomeric FGF1, which may enter systemic circulation or sequestered in tissues bind to heparan sulfate proteoglycans of the extracellular matrix. Then, FGF1 can connect and provide their effects through specific receptor fibroblast growth factor whisky proteins which are a family of closely related molecules.

In addition to his activity extracellular FGF1 can also act intracellularly. Protein has a nuclear localization sequence NLS, and but the route by which FGF1 is enough to reach the core is not clear and it seems that some cell surface receptors necessary, after internalization and translocation into the nucleus, after which it can interact with nuclear isoforms of FGFRs. This is different from FGF2, which can also activate FGFRs but nuclear splicing variants of the protein that never leave the cell and go directly to the core.

                                     
  • FGF1 is also known as acidic fibroblast growth factor, and FGF 2 is also known as basic fibroblast growth factor. Members FGF 11, FGF 12, FGF 13, and FGF 14
  • The FGF - 1 internal ribosome entry site IRES is an RNA element present in the 5 UTR of the mRNA of fibroblast growth factor - 1 and allows cap - independent
  • humans is encoded by the FGF 17 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess
  • humans is encoded by the FGF 10 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess
  • humans is encoded by the FGF 4 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess
  • humans is encoded by the FGF 8 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess
  • Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF 19 gene. It functions as a hormone, regulating bile acid synthesis, with effects
  • protein 1 is a protein that in humans is encoded by the FGFBP 1 gene. FGFBP 1 or HBP17, binds to both acidic FGF1 MIM 131220 and basic FGF 2 MIM 134920
  • humans is encoded by the FGF 9 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess
  • also known as FGF - 3 is a protein that in humans is encoded by the FGF 3 gene. FGF - 3 is a member of the fibroblast growth factor family. FGF 3 binds to Fibroblast
  • humans is encoded by the FGF 13 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess