ⓘ CBR96-doxorubicin immunoconjugate

                                     

ⓘ CBR96-doxorubicin immunoconjugate

cBR96-doxorubicin immunoconjugate is an antibody-drug conjugate or directed to the Lewis-Y antigen designed for the treatment of cancer. The payload is the chemotherapy drug doxorubicin which is connected with a hydrazone linker to cysteine residues of the Lewis-Y specific monoclonal antibody BR96. Following internalization, the hydrazone is hydrolyzed within the acidic environment of target cell endosomes and lysosomes to release active cytotoxic drug.