ⓘ Genetics of migraine headaches

                                     

ⓘ Genetics of migraine headaches

Because genetics influence susceptibility to migraine, it can be shaped by evolution. Fitness-impairing disorders, including severe headache, tend to disappear as a result of natural selection, and their frequency decreases to near the rate of spontaneous mutation. However, migraine has not diminished over millions of years of evolution. Its prevalence has at least been maintained at a high level, and has even been shown to be increasing. This phenomenon suggests that a central nervous system susceptible to severe, intermittent headache has been linked to an important survival or reproductive advantage. Five possible evolutionary explanations exist: i) migraine as a defense mechanism, ii) migraine as a result of conflicts with other organisms, iii) migraine as a result of novel environmental factors, iv) migraine as a compromise between genetic harms and benefits, and v) headache as a design constraint. These considerations allow the treatment and prevention of migraine to be approached from an evolutionary medicine perspective.

                                     
  • migraine is a primary headache disorder characterized by recurrent headaches that are moderate to severe. Typically, the headaches affect one half of
  • of the body. Signs of a hemiplegic migraine attack are similar to what would be presented in a stroke that typically includes sudden severe headache on
  • Cluster headache CH is a neurological disorder characterized by recurrent severe headaches on one side of the head, typically around the eye. There
  • Sporadic hemiplegic migraine SHM is a form of hemiplegic migraine headache isolated cases of which are observed. It is a rare disease. It is considered
  • Familial hemiplegic migraine FHM is an autosomal dominant type of hemiplegic migraine that typically includes weakness of half the body which can last
  • hemiplegic migraine - an experimental genetic headache model PhD Jakob Moller Hansen, 2009 Possible role of prostanoids in migraine and other headaches PhD
  • vivo models as well as experimental human headache models, human genetics and epidemiology and development of new treatment approaches. DHC encompasses
  • manifestations associated with MT - TV mutations have included recurrent migraine headaches muscle weakness and poor coordination, hearing loss, learning disabilities
  • role of genetics in characteristics as varied as adult height, brain volume, intelligence, migraine headaches anxiety, drug addiction, and love of coffee
  • on one side of the body hemiparesis altered consciousness, vision abnormalities, seizures, and severe headaches resembling migraines Repeated stroke - like