ⓘ Uroporphyrinogen III decarboxylase

                                     

ⓘ Uroporphyrinogen III decarboxylase

Uroporphyrinogen III decarboxylase is a homodimeric enzyme PDB: 1URO ​ that catalyzes the fifth step in heme biosynthesis, which corresponds to the elimination of carboxyl groups from the four acetate side chains of uroporphyrinogen III to yield coproporphyrinogen III:

uroporphyrinogen III ⇌ {\displaystyle \rightleftharpoons } coproporphyrinogen III + 4 CO 2
                                     
  • the enzyme uroporphyrinogen III synthase, and is further converted into coproporphyrinogen III by the enzyme uroporphyrinogen III decarboxylase The II
  • hemes and chlorophylls, uroporphyrinogen III is converted into coproporphyrinogen III by the enzyme uroporphyrinogen III decarboxylase In the biosynthesis
  • Coproporphyrinogen III is the most common variance. In the metabolism of porphyrin, it is formed from uroporphyrinogen III by the enzyme uroporphyrinogen III decarboxylase
  • fixation of carbon dioxide Uridine monophosphate synthetase Uroporphyrinogen III decarboxylase Enzymes Lyases List of EC numbers of enzymes belonging to
  • hepatic porphyria caused by a disorder in both genes which code Uroporphyrinogen III decarboxylase UROD It has a similar presentation to porphyria cutanea
  • pathway, coproporphyrinogen III is derived from uroporphyrinogen III by the action of the enzyme uroporphyrinogen III decarboxylase The conversion entails
  • synthesized, uroporphyrinogen I is then converted into coproporphyrinogen I by the same enzyme uroporphyrinogen decarboxylase that acts on the III form but
  • I is produced instead of uroporphyrinogen III. The enzyme uroporphyrinogen III decarboxylase will also act on the I isomer, producing coproporphyrinogen
  • sunlight. The primary cause of this disorder is a deficiency of uroporphyrinogen decarboxylase UROD a cytosolic enzyme that is a step in the enzymatic pathway
  • decarboxylase EC 4.1.1.36: phosphopantothenoylcysteine decarboxylase EC 4.1.1.37: uroporphyrinogen decarboxylase EC 4.1.1.38: phosphoenolpyruvate carboxykinase