ⓘ Acid sphingomyelinase
Acid sphingomyelinase is one of the enzymes that make up the sphingomyelinase family, responsible for catalyzing the breakdown of sphingomyelin to ceramide and phosphorylcholine. They are organized into alkaline, neutral, and acidic SMase depending on the pH in which their enzymatic activity is optimal. Acid Sphingomyelinases enzymatic activity can be influenced by lipids, cations, pH, redox and other proteins in the environment. Specifically aSMases have been shown to have increased enzymatic activity in lysobisphophatidic acid or phosphatidylinositol enriched environments, and inhibited activity when phosphorylated derivatives of PI are present.
Sphingomyelin phosphodiesterase 1 is a gene that encodes aSMase two enzymes differ in their pools of Sphingomyelin hydrolysis. Lysosomal sphingomyelinase n-smase in the lysosomal compartment and secretory sphingomyelinase s-smase is extracellular.