ⓘ Stimulator of interferon genes
Stimulator of interferon genes, also known as transmembrane protein 173 and MPYS/MITA/ERIS is a protein that in humans is encoded by the TMEM173 gene.
Sting plays an important role in innate immunity. Sting induces type I interferon production when cells infected with intracellular pathogens such as viruses, mycobacteria and intracellular parasites. Type I interferons, through the sting protects the infected cells and nearby cells from local infection by binding to the same cell that secretes it and autocrine signaling nearby cells paracrine signals.
Sting is encoded by the gene TMEM173. It works as a direct cytosolic sensor of DNA CD-ROM drive and the adapter protein type I interferon signal through different molecular mechanisms. This has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and the innate immune response against intracellular pathogens.
- cells. In addition, interferons induce production of hundreds of other proteins - known collectively as interferon - stimulated genes ISGs - that have roles
- expression of IFNA IFNB genes is primarily controlled at the gene transcription level, by the interferon regulatory factors IRFs and IFN - stimulated genes Viruses
- leading to the expression of numerous interferon - stimulated genes with anti - viral and anti - proliferative effects. All four interferon lambda proteins have
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- An interferon - stimulated gene ISG is a gene whose expression is stimulated by interferon Interferon activates the JAK - STAT signaling pathway to induce
- interferons IFNs are a large subgroup of interferon proteins that help regulate the activity of the immune system. Interferons bind to interferon receptors
- immune interferon was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen - stimulated
- or suppress the transcription of over 2000 different genes For example, type I IFNs induce interferon - stimulated gene ISG expression, classically resulting
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