ⓘ P110δ

                                     

ⓘ P110δ

Phosphatidylinositol-4.5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase delta isoform or p110δ is an enzyme that in humans is encoded by the PIK3CD gene.

p110δ regulates immune function. In contrast to the other class IA PI3Ks p110a and p110ß, p110δ is mainly expressed in leukocytes are white blood cells. Genetic and pharmacological inactivation of p110δ showed that this enzyme is essential for the function of T cells mast cells, and neutrophils. Hence, p110δ is a promising target for drugs that aim to prevent or treat inflammation, autoimmune diseases and transplant rejection.

Phosphatidylinositol-3-kinases PI3Ks phosphorylate the 3-Prime Oh position of the Inositol ring of Inositol lipids. Class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110a, p110ß and p110y. p110a and p110ß to interact with ø2 / SH3-domain-containing P85 adapter proteins and GTP-bound RAS.