ⓘ Common gamma chain

                                     

ⓘ Common gamma chain

The common gamma chain, also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. The γ c glycoprotein is a member of the type I cytokine receptor family expressed on most lymphocyte populations, and its gene is found on the X-chromosome of mammals.

This protein is located on the surface of immature hematopoietic cells in the bone marrow. One end of the protein is outside the cell, where it binds the cytokines, and the other end of the protein resides in the interior of the cell where it transmits signals to the cell nucleus. Common gamma chain partners with other proteins to direct blood-forming cells in the form of lymphocytes, a type of white blood cells. The receptor also directs the growth and maturation of lymphocyte subtypes: T cells, b cells and natural killer cells. These cells kill viruses, antibodies, and help regulate the entire immune system.