ⓘ CD38

                                     

ⓘ CD38

CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells, including CD4 +, CD8 +, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.

In humans the protein encoded by CD38 gene which located on chromosome 4.

                                     
  • Dianzani U, Stockinger H, Malavasi F 1998 Human CD38 ADP - ribosyl cyclase is a counter - receptor of CD 31, an Ig superfamily member J. Immunol. 160 1
  • Daratumumab trade name Darzalex is an anti - cancer drug. It binds to CD38 which multiple myeloma cells overexpress. Daratumumab was originally developed
  • for this gene. CD 247 has been shown to interact with Janus kinase 3 and Protein unc - 119 homolog. Cluster of differentiation ZAP70 GRCh 38 Ensembl release
  • IL - 4. CD 14 has been shown to interact with lipopolysaccharide - binding protein. GRCh 38 Ensembl release 89: ENSG00000170458 - Ensembl, May 2017 GRCm 38 Ensembl
  • observed as CD 34 and CD38 - are of an undifferentiated, primitive form i.e., they are multipotential hemopoietic stem cells. Thus, because of their CD 34 expression
  • structure of the human CD 53 gene Immunogenetics. 38 4 272 279. doi: 10.1007 BF00188803. PMID 8319976. Entrez Gene: CD 53 CD 53 molecule Horejsi V
  • antibody that binds to CD 27 and is an experimental cancer treatment. CD 27 has been shown to interact with SIVA1, TRAF2 and TRAF3. GRCh 38 Ensembl release 89:
  • second as adhesion receptors. CD 164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor. GRCh 38 Ensembl release 89: ENSG00000135535
  • molecule. CD 22 has been shown to interact with Grb2, PTPN6, LYN, SHC1 and INPP5D. GRCh 38 Ensembl release 89: ENSG00000012124 - Ensembl, May 2017 GRCm 38 Ensembl