ⓘ Thiopurine methyltransferase

                                     

ⓘ Thiopurine methyltransferase

Thiopurine methyltransferase or thiopurine S-methyltransferase is an enzyme that in humans is encoded by the TPMT gene. A pseudogene for this locus is located on chromosome 18q.

                                     
  • Tartu Youth Academy. As a student she worked on the action of thiopurine methyltransferase Tamm was born in Tartu and grew up in the village of Peri, near
  • Examples of methyltransferase enzymes relevant to disease: thiopurine methyltransferase defects in this gene causes toxic accumulation of thiopurine compounds
  • when on the medication. People with a genetic deficiency in thiopurine S - methyltransferase are at higher risk of side effects. Avoiding pregnancy when
  • The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders e.g., Crohn s disease
  • deficiency in thiopurine S - methyltransferase are at higher risk of side effects. Use in pregnancy may harm the baby. Mercaptopurine is in the thiopurine and antimetabolite
  • especially common in people with a genetic deficiency of the enzyme thiopurine S - methyltransferase Other serious risk factors include an increased risk of lymphoma
  • 65: licodione 2 - O - methyltransferase EC 2.1.1.66: rRNA adenosine - 2 - O - - methyltransferase EC 2.1.1.67: thiopurine S - methyltransferase EC 2.1.1.68: caffeate
  • available hypomethylating agents block the activity of DNA methyltransferase DNA methyltransferase inhibitors DNMT inhibitors Currently two members of
  • reduction of the thiopurine usually to one - third of the standard dose depending upon the patient s genetic status for thiopurine methyltransferase Because allopurinol
  • and procainamide. Inheriting abnormal thiopurine S - methyltransferase may affect the metabolism of the thiopurine drugs mercaptopurine and azathioprine
  • Mlinaric - Rascan, I August 2009 Individualization of thiopurine therapy: thiopurine S - methyltransferase and beyond Pharmacogenomics. 10 8 1309 22. doi: 10