ⓘ Glucocerebrosidase

                                     

ⓘ Glucocerebrosidase

β-Glucocerebrosidase is an enzyme with glucosylceramidase activity that is needed to cleave, by hydrolysis, the beta-glucosidic linkage of the chemical glucocerebroside, an intermediate in glycolipid metabolism that is abundant in cell membranes. It is localized in the lysosome, where it remains associated with the lysosomal membrane. β-Glucocerebrosidase is 497 amino acids in length and has a molecular weight of 59.700 Daltons.

                                     
  • glucocerebroside - specific enzyme, which is a recombinant form of glucocerebrosidase indicated as a long - term enzyme replacement therapy for those suffering
  • GlcCer - beta - glucosidase, beta - D - glucocerebrosidase glucosylcerebrosidase, beta - glucosylceramidase, ceramide glucosidase, glucocerebrosidase glucosylsphingosine
  • Beutler E, West C, Gelbart T 1992 Polymorphisms in the human glucocerebrosidase gene Genomics. 12 4 795 800. doi: 10.1016 0888 - 7543 92 90311 - F
  • biopharmaceutical drug developed by Protalix and Pfizer. The drug, a recombinant glucocerebrosidase used to treat Gaucher s disease, was the first plant - made pharmaceutical
  • its development. The substance was used in form of the tartrate. β - Glucocerebrosidase an enzyme needed for the metabolisation of glucocerebroside, is misfolded
  • and spleen, and is caused by a hereditary deficiency of the enzyme glucocerebrosidase also known as glucosylceramidase which acts on glucocerebroside
  • It is a recombinant DNA - produced analogue of the human enzyme β - glucocerebrosidase Cerezyme is a freeze - dried medicine containing imiglucerase, manufactured
  • treatment of Gaucher s disease. It was a modified form of human β - glucocerebrosidase enzyme, where the non - reducing ends of the oligosaccharide chains
  • 1960 235: 3099 3103. Brady RO, Kanfer JN, Shapiro, D. Metabolism of glucocerebrosidase II. Evidence of an enzymatic deficiency in Gaucher s disease. Biochem
  • Global Corruption Barometer Gloucestershire Cricket Board, in England Glucocerebrosidase enzyme Dame or knight Grand Cross of the order of the Bath Green