ⓘ SLC41A3

                                     

ⓘ SLC41A3

Model organisms have been used in the study of SLC41A3 function. A conditional knockout mouse line, called Slc41a3 tm1aKOMPWtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standard screen to determine the phenotypic consequences of the deletion. Twenty-six tests were performed on mutant mice and one significant abnormality was observed: the homozygous mutants displayed impaired coordination of movements of the musculoskeletal system.