ⓘ OTUD6B

                                     

ⓘ OTUD6B

OTU domain containing 6B is a protein that in humans is encoded by the OTUD6B gene.

OTUD6B is a functional deubiquitinating enzyme class of proteases which specifically cleaves ubiquitin linkages, negating the action of ubiquitin ligase. OTUD6B, also known as DUBA5 belongs to a dub subfamily characterized by ovarian tumors OTU domain. Function OTUD6B may be associated with growth and proliferation. This hypothesis is supported by a recent study, according to which OTUD6B knock out mice, obtained using the exon 4 deletion, are subviable and smaller in size. People OTUD6B mutations have been associated with a syndrome of mental retardation associated with dysmorphic features.

Previous studies on model organisms, see below, cannot be tested using this editor.

Model organisms have been used in the study of functions OTUD6B. Imaginary line of knockout mice, called Otud6b tm1aEUCOMMWtsi was created in the framework of the international program Consortium knockout mouse mutagenesis high-performance project, create and distribute animal models of disease to interested scientists.

Male and female animals underwent a standard screen to determine the phenotypic consequences of the deletion. Twenty-five tests were performed on homozygous mutant adult mice, but no significant deviations are observed.

                                     
  • OTU domain - containing protein 7 B is a protein that in humans is encoded by the OTUD 7 B gene. GRCh38: Ensembl release 89: ENSG00000264522 - Ensembl, May
  • domain - containing protein 4 is a protein that in humans is encoded by the OTUD 4 gene. Two alternatively spliced transcript variants encoding distinct isoforms
  • light polypeptide 68kDa ODF1: outer dense fiber protein 1 OTUD6B OTU domain containing 6 B PDP1: pyruvate dehydrogenase phosphatase catalytic subunit
  • NOA1: encoding protein Nitric oxide associated 1 NUDT 6 nudix hydrolase 6 NUDT9: nudix hydrolase 9 OTUD 4: OTU domain - containing protein 4 PABPC4L: encoding
  • receptor - binding factor 2 NSMCE4A: non - SMC element 4 homolog A OTUD 1: encoding protein OTU deubiquitinase 1 PCBD1: 6 - pyruvoyl - tetrahydropterin synthase dimerization
  • The Lotud women were known to wear skirts below the knees only. The word otud in Dusun Lotud dialect means Lutut or knee. A husband from ethnic Dusun
  • valosin - containing protein - like OLFML2 B Olfactomedin - like 2 B OPTC: Opticin OTUD 7 B OTU domain - containing protein 7 B PACERR encoding protein PTGS2 antisense
  • containing 2 NKRF: encoding protein NF - kappa - B - repressing factor NRK: encoding enzyme Nik - related protein kinase OTUD 5: encoding protein OTU deubiquitinase 5