ⓘ Antithyroid autoantibodies

                                     

ⓘ Antithyroid autoantibodies

Antithyroid autoantibodies are autoantibodies targeted against one or more components on the thyroid. The most clinically relevant anti-thyroid autoantibodies are anti-thyroid peroxidase antibodies, thyrotropin receptor antibodies and thyroglobulin antibodies. TRAbs are subdivided into activating, blocking and neutral antibodies, depending on their effect on the TSH receptor. Anti-sodium/Iodide symporter antibodies are a more recent discovery and their clinical relevance is still unknown. Graves disease and Hashimotos thyroiditis are commonly associated with the presence of anti-thyroid autoantibodies. Although there is overlap, anti-TPO antibodies are most commonly associated with Hashimotos thyroiditis and activating TRAbs are most commonly associated with Graves disease. Thyroid microsomal antibodies were a group of anti-thyroid antibodies, they were renamed after the identification of their target antigen.

                                     
  • 2007.0310. PMID 18631006. Nagasaka A, Hidaka H Jul 1976 Effect of antithyroid agents 6 - propyl - 2 - thiouracil and 1 - mehtyl - 2 - mercaptoimidazole on human
  • findings: Raised protein 25 cases Negative for 14 3 3 protein May contain antithyroid antibodies Magnetic resonance imaging abnormalities consistent with encephalopathy
  • Medications such as beta blockers may control some of the symptoms, and antithyroid medications such as methimazole may temporarily help people while other
  • hyperthyroidism caused by Graves disease can be managed with iodine therapy, antithyroid medication, or surgical removal of the thyroid gland. Thyroid surgery
  • Cimini N, Conte F, Gentile M, Papa N, Carnevale A February 2003 Antithyroid antibodies in the CSF: Their role in the pathogenesis of Hashimoto s
  • thyroid autoantibody titres, which reflect organ destruction due to autoimmunity. Elevated SPINA - GT in Graves s disease is reversible with antithyroid treatment
  • long - term quality - of - life follow - up of patients randomized to treatment with antithyroid drugs, radioiodine, or surgery, Thyroid 15, no. 11 2005 1279 86 Numbers
  • initially elevated SPINA - GD decreaes with antithyroid treatment in parallel to declining TSH receptor autoantibody titres. In hyperthyroid men both SPINA - GT
  • including drugs non - steroidal anti inflammatory drugs, antiepileptics, antithyroid and antibiotics and viral infection. Agranulocytosis has a mortality