ⓘ Proximal renal tubular acidosis

                                     

ⓘ Proximal renal tubular acidosis

Proximal renal tubular acidosis or type 2 renal tubular acidosis is a type of RTA caused by a failure of the proximal tubular cells to reabsorb filtered bicarbonate from the urine, leading to urinary bicarbonate wasting and subsequent acidemia. The distal intercalated cells function normally, so the acidemia is less severe than dRTA and the urine can acidify to a pH of less than 5.3. pRTA also has several causes, and may occasionally be present as a solitary defect, but is usually associated with a more generalised dysfunction of the proximal tubular cells called Fanconi syndrome where there is also phosphaturia, glycosuria, aminoaciduria, uricosuria and tubular proteinuria.

Patients with type 2 of the mouth usually hypokalemic due to the combination of secondary hyperaldosteronism and loss of urine potassium, although potassium level in the blood may be falsely elevated due to acidosis. The office of bicarbonate before the addition of potassium can lead to hypokalemia worsened, and shifts of potassium from the intracellular alkalizing.

The main characteristic of Fanconi syndrome demineralization of bone osteomalacia and rickets due to phosphate and vitamin D in vain.

                                     
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  • HCO 3 i.e., proximal renal tubular acidosis RTA also known as type 2 RTA Kidney dysfunction i.e., distal renal tubular acidosis also known as type
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