ⓘ Linear epitope

                                     

ⓘ Linear epitope

A linear or a sequential epitope is an epitope that is recognized by antibodies by its linear sequence of amino acids, or primary structure. In contrast, most antibodies recognize a conformational epitope that has a specific three-dimensional shape and its protein structure.

An antigen is any substance that the immune system can recognize as foreign and that triggers immune response. Since the antigens are usually proteins are too large to bind to any receptor, only specific segments that form the antigen bind with specific antibodies. Such segments are called epitopes. In addition, it is only paratope of the antibody that makes contact with the epitope.

Proteins are composed of repeating nitrogen-containing subunits called amino acids. Linear sequence of amino acids constituting a protein is called its primary structure, which is usually not present as a simple serial protein as a node, not a straight line. However, when the antigen is broken down in the lysosome, it gives small peptides that can be recognized by amino acids, which always lie in a line, and hence are called linear epitopes.

                                     
  • diseases are also epitopes The epitopes of protein antigens are divided into two categories, conformational epitopes and linear epitopes based on their
  • line. These are known as linear epitopes Antigen Linear epitope Epitope mapping, finding on an antigen protein the epitope s for a specific antibody
  • sequence and or structural data. Epitopes are generally divided into two classes: linear and conformational. Linear epitopes are formed by a continuous sequence
  • Further studies have expanded the ideal epitope beyond ELDKWAS and revealed that the extended linear epitope NEQELLELDKWASLWN increased 2F5 affinity greatly
  • cell this explanation is too simplistic. Such epitopes are known as sequential or linear epitopes as all the amino acids on them are in the same sequence
  • Schafer C, Schneider C, Bautz FA 1999 Identification of major linear epitopes on the sp100 nuclear PBC autoantigen by the gene - fragment phage - display
  • capture microdissection - leucine zipper - leukemia - library - ligase - linear epitope - linkage - linker protein - lipofectin - locus - LOD score - lymphocyte
  • and need not be linear or of a rate - limited step or equation. Antigenic escape Antitoxin Conformational epitope Epitope Linear epitope Magnetic immunoassay
  • allergoid sustain the linear epitopes recognized by the MHC - TCR cell - present systems keeps the immunoreactivity but has less reaginic epitopes less allergenicity
  • A peptide microarray also commonly known as peptide chip or peptide epitope microarray is a collection of peptides displayed on a solid surface, usually
  • their protein products. Either the linear amino acid sequence or the conformational fit of the immunodominant epitope may be shared between the pathogen