ⓘ IRGM

                                     

ⓘ IRGM

Immunity-related GTPase family M protein, also known as interferon-inducible protein 1, is an enzyme that in humans is IRGM gene.

IRGM is a member of the interferon-inducible family of GTP-Aza. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens.

                                     
  • localization of IRGs are variable Irga6 and Irgm 3 are predominantly found within the endoplasmic reticulum, Irgm 1 and Irgm 2 have been localized to the Golgi apparatus
  • superoxide anion. GULO pseudogene, associated with the production of Vitamin C IRGM pseudogene, associated with the immune system hHaA pseudogene, associated
  • Mediated mRNA Decay Factor SMG9 There is one paralog for IRGC named IRGM IRGM or immunity related GTPase M, is associated with intracellular defense
  • Deretic s group shows how the human immunity related GTPase IRGM works in autophagy by demonstrating IRGM s direct interactions with the core autophagy ATG
  • Hofman P 2011 A synonymous variant in IRGM alters a binding site for miR - 196 and causes deregulation of IRGM - dependent xenophagy in Crohn s disease
  • Independent and population - specific association of risk variants at the IRGM locus with Crohn s disease PDF Hum. Mol. Genet. 19 9 1828 39. doi: 10
  • frame ORF causing the rebirth of the human immunity related GTPase gene IRGM ERV insertions have also been shown to generate alternative splice sites