ⓘ Somatic hypermutation

                                     

ⓘ Somatic hypermutation

Somatic hypermutation is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it, as seen during class switching. A major component of the process of affinity maturation, SHM diversifies B cell receptors used to recognize foreign elements and allows the immune system to adapt its response to new threats during the lifetime of an organism. Somatic hypermutation involves a programmed process of mutation affecting the variable regions of immunoglobulin genes. Unlike germline mutation, SHM affects only an organisms individual immune cells, and the mutations are not transmitted to the organisms offspring. Mistargeted somatic hypermutation is a likely mechanism in the development of B-cell lymphomas and many other cancers.

                                     
  • immunoglobulin of germinal center B cells and as a direct result of somatic hypermutation SHM and selection by Tfh cells. The process is thought to involve
  • recombination downstream of the AICDA gene that does not impair somatic hypermutation Lougaris V, Badolato R, Ferrari S, Plebani A 2005 Hyper immunoglobulin
  • systems shmat, shmctl, etc. Simple harmonic motion in physics Somatic hypermutation allowing immune system adaptation Structural health monitoring
  • reproduction is inspired by cell division, and variation is inspired by somatic hypermutation Clonal selection algorithms are most commonly applied to optimization
  • member of the cytidine deaminase family. The protein is involved in somatic hypermutation gene conversion, and class - switch recombination of immunoglobulin
  • proliferate, differentiate, and mutate their antibody genes through somatic hypermutation aimed at achieving higher affinity during a normal immune response
  • Deaminase AICDA and functions as a DNA - editing deaminase that induces somatic hypermutation class switch recombination, and immunoglobulin gene conversion
  • centroblasts to express activation - induced cytidine deaminase, leading to somatic hypermutation Morphologically, centroblasts are large lymphoid cells containing
  • deaminase AID that is essential for class switch recombination and somatic hypermutation He was elected as a foreign associate of the National Academy of
  • signaling via B cells affecting class switch recombination CSR and somatic hypermutation Immunoglobulin Ig class switch recombination deficiencies are