ⓘ Reprimo

                                     

ⓘ Reprimo

Reprimo, is a gene located at human chromosome 2q23 whose expression in conjunction with p53, along with other genes which are p53-induced, is associated with the arrest of the cell cycle at the G2 phase. Reprimos protein product is a highly glycosylated polypeptide which, upon its expression, is localized to the cytoplasm where it is primarily active. As the expression of reprimo is controlled by p53, which is in turn controlled by a wide array of convergent signal pathways pertaining to DNA damage or nutrient depravity, its presence is expected within cells which would cause damage should they be freely allowed to replicate. Pursuant to this, r eprimo s expression during the G2 phase of the cell cycle ultimately results in the reduction of Cdc2 expression, and in the inhibition of the nuclear translocation of cyclin B1 which is necessary to its function. Reprimo is known to collaborate with p21 to achieve these specific effects, and in a more general sense collaborates with the other p53-induced proteins and effectors to produce the overall cellular response. These regulatory actions help to render the afflicted cell into an arrested state which is less immediately threatening to the whole organism due to the inability of afflicted cells to replicate with damaged DNA, among other potential circumstances, giving the cell an opportunity to undergo DNA repair or apoptosis as the level of damage will dictate. Indefinite cell cycle arrest is another potential outcome. For this reason, it is considered to be a tumor suppressor gene.

Identification of this gene repression via methylation in their region upstream of the promoter in different types of cancerous tissue was used to suggest a link with the formation of said cancer. These events typically cause aberrant splicing methylation of DNA, which can lead to one of the many potential errors as a result, the mutant reprimo, which ultimately undermines its ability to be expressed, from the supposed effect, or accumulate in sufficient quantity to produce the expected arrest of the reaction. The variability of these results due to the high probability that the space for these point mutations. There are also studies suggesting that these genes condition expression in specific tissues can be useful information for the diagnosis or prediction of certain types of cancer.