ⓘ Terminal deoxynucleotidyl transferase

                                     

ⓘ Terminal deoxynucleotidyl transferase

Terminal deoxynucleotidyl transferase, also known as DNA nucleotidylexotransferase or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells. TdT adds N-nucleotides to the V, D, and J exons of the TCR and BCR genes during antibody gene recombination, enabling the phenomenon of junctional diversity. In humans, terminal transferase is encoded by the DNTT gene. As a member of the X family of DNA polymerase enzymes, it works in conjunction with polymerase λ and polymerase μ, both of which belong to the same X family of polymerase enzymes. The diversity introduced by TdT has played an important role in the evolution of the vertebrate immune system, significantly increasing the variety of antigen receptors that a cell is equipped with to fight pathogens. Studies using TdT knockout mice have found drastic reductions in T-cell receptor diversity compared with that of normal, or wild-type, systems. The greater diversity of TCRs that an organism is equipped with leads to greater resistance to infection.

TDT is absent in the CCM fetal liver significantly impairing the nodal diversity of b-cells in the fetal period.

                                     
  • Tunel or Tunel may refer to: TUNEL assay Terminal deoxynucleotidyl transferase mediated dUTP Nick End Labeling assay in genetics, a method for detecting
  • addition of these nucleotides is aided by an enzyme called Terminal deoxynucleotidyl transferase TdT Sandor, Z Calicchio, ML Sargent, RG Roth, DB Wilson
  • Terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL is a method for detecting DNA fragmentation by labeling the 3 - hydroxyl termini
  • polymerase IV DinB SOS repair polymerase Pol β, λ, μ Terminal deoxynucleotidyl transferase TDT which lends diversity to antibody heavy chains. Family
  • Dillon Thomas Banda fl. 1957 1962 Nyasaland politician Terminal deoxynucleotidyl transferase a specialized DNA polymerase expressed in immune cells
  • addition of non - coded nucleotides during recombination by terminal deoxynucleotidyl transferase P nucleotide insertion is the insertion of palindromic
  • palindromic, P nucleotides. Subsequent to this, the enzyme, terminal deoxynucleotidyl transferase TdT adds further random N nucleotides. The newly synthesised
  • magnesium - containing buffers Nucleotides are added at the open ends by terminal deoxynucleotidyl transferase TdT This occurs until there are complementary sequences
  • the double - strand break. Pol μ is also closely related to terminal deoxynucleotidyl transferase TdT a specialized DNA polymerase that adds random nucleotides
  • respiratory burst. Thymosin β4 induces the activity of the enzyme terminal deoxynucleotidyl transferase in populations of thymocytes thymus - derived lymphocytes