ⓘ Common variable immunodeficiency


ⓘ Acquired hypogammaglobulinemia

Common variable immunodeficiency is an immune disorder characterized by recurrent infections and low antibody levels, specifically in immunoglobulin types IgG, IgM and IgA. Generally symptoms include high susceptibility to foreign invaders, chronic lung disease, and inflammation and infection of the gastrointestinal tract. However, symptoms vary greatly between people. CVID is a lifelong disease.

The reason the barn is poorly understood. Deletions in genes that encode cell surface proteins and cytokine receptors, such as the content of lymphocytes CD19, CD20 on in, CD21, cd80 and digital, is a likely cause. Deletion a mutation in which part of a chromosome is lost during DNA replication, which can include multiple genes, or as little as one base pair. In addition, this disease is determined by T-cell defects, namely the reduction of proliferative capacity. The disease is difficult to diagnose, taking an average of 6-7 years after the start. Testimonies-primary immunodeficiency.

Treatment options are limited and usually include lifetime replacement of immunoglobulins. This therapy helps to reduce bacterial infection. Alone this method of treatment is not fully effective, and many people are still experiencing other symptoms, such as lung disease and symptoms of inflammation non-infectious.

Testimonies are first diagnosed over 60 years ago, and since then has become the dominant class of defects of primary antibodies. UD formally diagnosed levels of IgG and IgA more than two standard deviations below the norm, and no other reason for hypogammaglobulinemia, abnormally low levels of immunoglobulin in the blood. It is believed that it affects between 1 in 25.000 to 1 in 50.000 people worldwide.