ⓘ Endothelin 2

                                     

ⓘ Endothelin 2

Endothelin 2 is a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation.

Endothelin 2 et-2 expression is mainly localized in granulosa cells within the follicle, as observed in bovine, mouse and human ovarian tissue. Endothelin 2 has functions in the follicle of the ovary associated with ovulation. E-2 causes severe reduction in the smooth muscle cells of ovarian tissue, and et-2 production is highest just before ovulation.

                                     
  • Endothelins are peptides with receptors and effects in many body organs. Endothelin constricts blood vessels and raises blood pressure. The endothelins
  • There are at least four known endothelin receptors, ETA, ETB1, ETB 2 and ETC, all of which are G protein - coupled receptors whose activation result in elevation
  • Endothelin receptor type A, also known as ETA, is a human G protein - coupled receptor. Endothelin receptor type A has been shown to interact with HDAC7A
  • An endothelin receptor antagonist ERA is a drug that blocks endothelin receptors. Three main kinds of ERAs exist: selective ETA receptor antagonists
  • Endothelin - 3 is a protein that in humans is encoded by the EDN3 gene. The protein encoded by this gene is a member of the endothelin family. Endothelins
  • Endothelin receptor type B, also known as ETB is a protein that in humans is encoded by the EDNRB gene. Endothelin receptor type B is a G protein - coupled
  • Endothelin - converting enzyme - 1 is involved in the proteolytic processing of endothelin - 1 EDN1 - 2 EDN 2 and - 3 EDN3 to biologically active peptides. GRCh38: Ensembl
  • processed to release a secreted peptide termed endothelin 1. Endothelin 1 is one of three isoforms of human endothelin Preproendothelin is precursor of the peptide
  • peptide endothelin constricts muscles in blood vessels, increasing blood pressure. Ambrisentan, which relaxes those muscles, is an endothelin receptor
  • of endothelin ET on the endothelin - A ETA receptor selectively by a factor of 6000 compared with the ETB It is a sulfonamide class endothelin receptor
  • vasoconstrictive properties of endothelin and are mainly used for the treatment of pulmonary arterial hypertension, atrasentan blocks endothelin induced cell proliferation
  • Macitentan trade name Opsumit is an endothelin receptor antagonist ERA approved for the treatment of pulmonary arterial hypertension PAH The other